In this version of Windows, Defender for Endpoint includes powerful analytics, security stack integration, and centralized management for better detection, prevention, investigation, response, and management.
Threat protection and Microsoft Defender for Endpoint: The Microsoft Defender for Endpoint platform includes the security pillars shown in the following diagram. Security: This version of Windows 10 includes security improvements for threat protection, information protection, and identity protection. 
However, note that Windows Update for Business (WUfB) does not currently support any LTSC releases, therefore you should use WSUS or Configuration Manager for patching. This includes support for features such as Windows Autopilot.
Microsoft Intune: Microsoft Intune supports Windows 10 Enterprise LTSC 2019 and later. Since Windows 10 LTSC is based on the Enterprise edition, there is a set of all necessary software and features to be used in corporate networks (Windows To Go, AppLocker, Local Group Policy Editor – gpedit.msc, you can join this Windows edition to the Active Directory domain, integrated Microsoft Application Virtualization (App-V) support and User Environment Virtualization (UE-V), Device Guard and Credential Guard, DirectAccess, Branch Cache, advanced telemetry management options, etc.). This is why Windows 10 LTSC may be installed on old models of PCs or laptops with 2 (or even 1!) GB of RAM. Because of the absence of unnecessary UWP apps, you don’t need to update them (the system downloads and installs only critical security updates), and there is fewer active processes number in the Task Manager. In addition, Windows 10 LTSC Start Menu is empty – you won’t see any icons of preinstalled apps. There is no hardware support for VP9/HEVC ( used on YouTube, encrypted video streams – Netflix, Amazon Video, etc.). Even a Photo Viewer must be enabled manually 
Preinstalled UWP apps (apps from Microsoft Store, both official and third-party ones).In Windows 10 Enterprise LTSC 2019, the operating system doesn’t have the following features In the Windows LTSC versions (earlier they were called LTSB – Long-Term Servicing Branch) Microsoft focuses on system stability. Windows LTSC version is a special Windows edition with long-term support. The Windows 10 Enterprise LTSC 2019 release is an important release for LTSC users because it includes the cumulative enhancements provided in Windows 10 (versions 1703, 1709, 1803, and 1809). Comprehensive device and app management and control capabilities.Advanced protection against modern security threats.Windows 10 Enterprise LTSC 2019 builds on Windows 10 Pro (version 1809) adding premium features designed to address the needs of large and mid-size organizations (including large academic institutions), such as:
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